Pharmacokinetic Study of Zaltoprofen Spherical Agglomerated Dense Compacts Canvassed with Commercial Product

The conventional tableting method used involves first making granules and then compressing into tablets, but the need in recent years for process validation, GMP and automation of production processes has focused renewal of attention on the direct tableting, which involves few steps [1]. Zaltoprofen, is a novel NSAID, selective COX2 inhibiting drug used in the treatment of rheumatoid arthritis and osteoarthritis and to relieve inflammation and pain after surgery [2]. Zaltoprofen exhibits poor flow and compression characteristics and hence Zaltoprofen selected as suitable candidate for spherical crystallization process to improve flow properties and compressibility. Further, Zaltoprofen shows poor oral bioavailability due to low aqueous solubility [3] hence in such case enhancing bioavailability is a valuable goal to improve therapeutic efficacy. Estimation of Zaltoprofen in plasma by methods like UV-visible spectrophotometric [4], Mass spectrometry in human plasma [5] was reported.